Lipid and Fatty Acid Composition of Organs from Copper-Deficient Mice

摘要: Experiments were conducted to study the total lipid and fatty acid composition of liver, kidney, brain heart 7-wk-old male C57BL mice. Dietary copper deficiency was initiated at birth by feeding dams a purified diet containing 0.5 mg/kg copper. Offspring fed copper-deficient 4 wk postweaning. Control offspring same but with added in drinking water, 20 mg/L. Compared controls mice exhibited hepatomegaly, cardiac hypertrophy 4% reduction weight as well low ceruloplasmin activity (0.5% control). Total phospholipid concentration liver kidney triacylglycerol lower compared concentrations measured control The major change essential which consistent between organs classes significantly proportion absolute amount dihomo-gamma-linolenic acid. Other changes variable.