Marine Fungi as Producers of Benzocoumarins, a New Class of Inhibitors of Glycogen-Synthase-Kinase 3β

摘要: The glycogen-synthase-kinase 3 (GSK-3) is an important target in drug discovery. This enzyme involved the signaling pathways of type 2 diabetes, neurological disorders, cancer, and other diseases. Therefore, inhibitors GSK-3 are promising candidates for treatment a broad range Here we report pannorin (1), alternariol (2), alternariol-9-methylether (3) to be isoform GSK-3β showing sub-μM IC50 values. vitro inhibition known highly active inhibitor TDZD-8. Compounds 1–3 have oxygenated benzocoumarin core structure common, which suggests that this may new structural feature efficient inhibition.