Investigation of the teratogenic potential of VLA-4 antagonist derivatives in rats.

摘要: Very late antigen-4 (VLA-4), which is concerned with cell-cell adhesion, plays important roles in development of the heart, and some VLA-4 antagonists cause cardiac anomalies. In this study, we evaluated teratogenic potential antagonist derivatives as screening, investigated conditions that induce Seventeen compounds were orally administered to pregnant rats throughout organogenesis period, fetal examinations performed. addition, drug concentrations embryos assayed. As a result, incidence ventricular septal defect (VSD) ranged from 0 100% depending on compound. Plasma dams related increased VSD; however, these incidences not when concentration compound at 24h after dosing was low. It considered continuous pharmacological activity embryo for more than might disrupt closure septum.