Quantification of the Binding of Insulin-like Growth Factor-I (IGF-I) and IGF Binding Protein-3 (IGFBP-3) Using Surface Plasmon Resonance
作者： Theresa Rachel Cassino
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摘要: II DEDICATION III AUTHOR'S ACKNOWLEDGEMENTS IV TABLE OF CONTENTS VI LIST FIGURES IX TABLES X CHAPTER 1 – INTRODUCTION 1.0 Overview of the Chapter 1.1 The Insulin-like Growth Factor Family 1.2 Interaction IGF-I and IGFBP-3 2 1.3 Importance pH 4 1.4 Binding Assays 1.5 Surface Plasmon Resonance 6 1.6 Thesis 11 LITERATURE REVIEW 13 2.0 2.1 Data Analysis 2.2 Review Previous SPR Studies Using Factors Proteins 22 2.3 Summary 29 3 LEICA MICROSYSTEMS BIO-SPR 9000 31 3.0 3.1 Leica System 3.2 Solutions used for Experiments 32 3.3 Activation Carboxymethylated Dextran Slide Immobilization 3.4 Preliminary 35 3.5 Initial Kinetic 36
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