A population of hoxb8 mutants and uses in identifying agents for treating repetitive behaviors

摘要: This invention provides in vivo and vitro methods of screening for an agent or a combination agents that reduces one more repetitive behaviors, comprising contacting neuronal cells animal with HOXB8 gene mutation the to be screened, determining whether behaviors is reduced biochemical correlates reduced, reduction indicating behaviors. The also method treating subject administering therapeutically effective dose identified by method. Further provided population animals mutation, wherein than 30% have excessive grooming less 10% show skeletal defects.