作者: Ann M. Graybiel , Esen Saka
DOI: 10.1016/S0896-6273(01)00575-X
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摘要: Excessive grooming behaviors, cleansing rituals, and self-mutilation are important features of a range neuropsychiatric diseases including obsessive compulsive (OC)-spectrum disorders. In this issue Neuron, Greer Capecchi (2002) report that Hoxb8 mutant mice exhibit behavioral phenotype. These mutants will be valuable in exploring the genetics pathophysiology OC-spectrum disorders as well strategies for their treatment.