Anti-cytokine autoantibodies: Epiphenomenon or critical modulators of cytokine action

摘要: Low amounts of high-affinity autoantibodies to various cytokines have been detected in sera from healthy donors. Their levels, although highly variable, are increased the circulation patients subjected cytokine therapy or suffering a variety immunoinflammatory diseases. It has suggested that these play regulatory role intensity and duration an immune response. The antibodies may prevent binding its specific cell surface receptor thereby neutralizing biological activity vivo. They also act as carrier proteins preventing rapid elimination thus increase bioactivity. Additionally alternatively, modulate cytokine-induced intracellular signal transduction pathways trigger complement-mediated cytotoxicity towards cells carrying membrane-bound cytokines. exert their compliance with other factors control activity, including soluble receptors, decoy antagonists. Although not favored by many investigators, less sophisticated for naturally occurring anti-cytokine should be considered well. Recent evidence shown generated at high frequency part response foreign antigens. These produced B arising process somatic mutation. Thus result “leaky” triggered processes.