Evolution of a cytokine using DNA family shuffling
作者： Chia-Chun J. Chang , Teddy T. Chen , Brett W. Cox , Glenn N. Dawes , Willem P.C. Stemmer
DOI: 10.1038/11737
关键词:
摘要: … DNA shuffling of a family of over 20 human interferon-α (Hu-IFN-α) genes was used to … in the first cycle of shuffling. After a second cycle of selective shuffling, the most active clone was …
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