COMTval158met polymorphism is associated with behavioral response and physiologic reactivity to socio-emotional stress in 4-month-old infants.

摘要: Abstract Individual variability exists in infants’ socio-emotional stress regulation, terms of behavioral response (i.e., negative emotionality) as well magnitude and direction increase or decrease ) hypothalamic-pituitary-adrenal (HPA) axis reactivity salivary cortisol post-stress concentration). The catechol- O -methyltransferase polymorphism at codon 158 (COMT val158met associates with but no evidence for infants. This study aimed to assess the association between COMT both emotionality 4-month-old Sixty-nine infants were exposed Face-to-Face Still-Face (FFSF) paradigm. During FFSF paradigm, is elicited by experimental manipulation maternal responsiveness episode). A double-exposure two episodes was used evaluate HPA reactivity. Negative 1-s microanalytically coded. Magnitude area under curve, AUC) Direction ( vs. concentration assessed. genotype categorized val -homozygotes met -carriers. Compared -homozygotes, -carriers showed higher during second episode. AUC greater increaser compared -homozygous In addition, presence an increasing response, allele emerged a specific risk condition face repeated exposures. present findings further extend previous studies conducted children adults suggesting that might be involved regulation early infancy, especially exposure.