Pulmonary permeability edema in a large animal model of nonpulmonary sepsis. A morphologic study.

摘要: Morphologic studies were undertaken in a sheep model of pulmonary permeability edema (PPE) induced by cecal ligation and perforation. Biopsies taken every 24 hours through 96 following induction sepsis showed, at hours, interstitial accompanied widespread aggregation polymorphonuclear leukocytes. This was confirmed electron microscopy, which also demonstrated endothelial cell swelling, platelet aggregation, fibrin deposition. By 48 "thromboangiitis" had developed that persisted hours. In vitro angiograms done 60 showed multiple filling defects; it possible to demonstrate these defects corresponded the "thromboangiitis." These thrombotic lesions, not result embolization from indwelling lines, closely resembled vascular changes described adult respiratory distress syndrome. It is believed this first time such lesions have been PPE resulting nonpulmonary sepsis.