Effect of dobutamine on lung microvascular fluid flux in sheep with "sepsis syndrome".

摘要: The effect on pulmonary fluid balance of adrenergic receptor agonist agents commonly employed in clinical sepsis has not been well characterized. Therefore, we tested the hypothesis that dobutamine would increase microvasular flux experimental sepsis-induced lung injury. To define effects this synthetic catecholamine lymph flow ( Q ˙ L ), infused sheep at two doses sequence (5µg/kg/min and 10µg/kg/min) before after induction intraperitoneal which resulted development microvascular In nonseptic state, cardiac output increased both 5µg/kg/min 10µg/kg/min (22 36 percent, respectively), while was unchanged from baseline (for 5µg, △ ; significant) 10µg, significant). Values for ratio lymph/plasma total protein levels ([L/P]TP) fell modestly study (p<0.05). With established syndrome, (2.99 ± 1.8 to 7.01 3.95 ml/15 min; p<0.05), without change [L/P]TP ratios or calculated hydrostatic pressure. (Pmv) During sepsis, infusion again associated with an (+ 29 percent) 33 doses, only lower dose (5µg/kg/min, p<0.05). model injury, systemic substantially augmenting .