Serum angiogenesis profile in gestational trophoblastic neoplasm using multiplex immunoassay.

摘要: Abstract Aims Gestational trophoblastic neoplasms (GTN) exemplify a rare, mostly curable but highly aggressive disease. It is often associated with rapid formation of distant metastases and most likely an intense neoangiogenesis processes. The aim the study was to analyze markers in serum patients GTN before chemotherapy compared healthy pregnant women. Main methods In this sixteen protein angiogenesis were evaluated 21 Markers measured using BioPlex Pro Human Cancer Biomarker Panel 1 immunoassay. t-Tests receiver operating characteristic curves used for statistical analysis. Key findings Receiver operator curve analysis identified six proteins (sTIE-2, osteopontin, sIL-6α, sVEGFR-2, sEGFR, PECAM-1) which had sufficient sensitivity specificity (AUC > 0,70) distinguish treatment from controls. levels three osteopontin sIL-6α) altered as controls (p = 0,0112; p = 0,0442; p = 0,0488, respectively) thereby may serve potential disease markers. Significance Serum concentration related changes course appear useful diagnostic process