A Specific Sympathomimetic Ergone in Adrenergic Nerve Fibres (Sympathin) and its Relations to Adrenaline and Nor-Adrenaline

摘要: Summary. Extracts have been prepared of various kinds nerves and their content sympathomimetic activity determined the actions analyzed. The thoracic lumbar sympathetic chain splenic periarterial were especially suitable for preparation active substance contained some 30–100 μg adrenaline equivalents per g as measured on blood pressure cat. The gives catechol reactions bears near relations to adrenaline, but differs characteristically from this in following respects, where a close resemblance nor-adrenaline was found: Blood action cat after ergotamine or dihydroergotamine (Fig. 2–4). Action non-pregnant cat's uterus 5 A), pregnant rabbit's 6) isolated intestine rabbit 7). Pupil-dilating 8). Fluorescence test. The occurs higher amounts grey rami than white 10). The is fairly high sensory skin low ganglia, vagus phrenic parts brain. After degeneration main portion (post-ganglionic) spleen greatly reduced. The possible physiological significance solubility ether presence phospho-lipids pointed out. From experiments it inferred that transmitter adrenergic nerve mammals identical with nor-adrenaline. Extracts frogs' hearts contain an properties adrenaline. It suggested name sympathin should be used ergone demonstrated nerves, exerting nor-adrenaline. The relationship E I discussed.