Histamine H1 receptor knockout mice exhibit impaired spatial memory in the eight-arm radial maze.

摘要: Background and purpose:  In the mammalian brain, histaminergic neurotransmission is mediated by postsynaptic histamine H1 H2 receptors presynaptic H3 autoreceptor, which also acts as a heteroreceptor. The receptor has been implicated in spatial learning memory formation. However, pharmacological lesion studies have revealed conflicting results. To examine involvement of reference working formation, knockout mice (KO) were tested eight-arm radial maze. Previously, we found that receptor-KO showed reduced emotionality when confronted with novelty. As it known emotions can an impact on performance, evaluated terms emotional behaviour light–dark box. Experimental approach:  Mice lacking wild-type (WT) for maze three arms baited one trial per day. Emotional was measured using test. Key results:  impaired task. No significant differences between WT observed test. Conclusions implications:  deficits might be due to reported changes cholinergic neurochemical parameters frontal cortex CA1 subregion hippocampus, synaptic plasticity and/or dysfunctional brain reward/reinforcement system.