Context-dependent effects of a single administration of mirtazapine on the expression of methamphetamine-induced conditioned place preference.

摘要: Re-exposure to cues repeatedly associated with methamphetamine (Meth) can trigger Meth-seeking and relapse in the abstinent abuser. Weakening conditioned Meth-associated memory during cue re-exposure may provide a means for relapse-reduction pharmacotherapy. Accordingly, we sought determine if atypical antidepressant mirtazapine disrupted long-term maintenance of Meth-induced place preference (CPP) when administered conjunction contextual conditioning cues, this effect was altered by Meth being present re-exposure. First, evaluated on CPP either saline- or Meth-paired chamber 12 days after conditioning. rats subsequently expressed independent chamber; but magnitude significantly less mirtazapine-treated re-exposed chamber. Next, ‘reinforced re-exposure’ context. Administration vehicle Meth, prior did not disrupt ability demonstrate day 20; however, CPP. These results indicate context-dependent mirtazapine, that is greatest tested combination injection cues.