Using conditioned place preference to identify relapse prevention medications

摘要: Stimuli, including contexts, which predict the availability or onset of a drug effect, can acquire conditioned incentive motivational properties. These properties endure after withdrawal, and promote drug-seeking may result in relapse. Conditioned place preference (CPP) assesses associations between drugs context they are experienced. Here, we review potential utility CPP procedures rodents humans to evaluate medications that target responses. We discuss translational procedure from humans, findings with FDA-approved treatments support use develop relapse-reduction medications. also challenges methodological questions applying this purpose. argue an efficient valid reduce burden full clinical trials drug-abusing patients currently required for testing promising treatments.