Treatment Outcomes of Treatment-Naïve Hepatitis C Patients Co-Infected with HIV: A Systematic Review and Meta-Analysis of Observational Cohorts

摘要: Introduction Co-infection with Hepatitis C (HCV) and HIV is common accelerates hepatic disease progression due to HCV. However, access HCV treatment limited success rates are generally poor. Methods We conducted a systematic review meta-analysis assess outcomes in observational cohorts. Two databases (Medline EMBASE) were searched using compound search strategy for cohort studies reporting (as determined by sustained virological response, SVR) HIV-positive patients initiating the first time. Results 40 included review, providing on 5339 from 17 countries. The pooled proportion of achieving SVR was 38%. Significantly poorer observed infected genotypes 1 or 4 (pooled 24.5%), compared 2 3 59.8%). who discontinued drug toxicities (reported 33 studies) low, at 4.3% (3.3–5.3%). Defaulting treatment, reported studies, also low (5.1%, 3.5–6.6%), as on-treatment mortality (35 0.1% (0–0.2%)). Conclusions These results, under programmatic conditions, comparable those randomised clinical trials, show that although poor co-infected patients, have HIV-negative patients.