Activity of gemifloxacin tested against Neisseria gonorrhoeae isolates including antimicrobial-resistant phenotypes

摘要: The antigonococcal potency of gemifloxacin and 5 reference comparator antimicrobials was determined for a selected collection gonococcal isolates. 250 Neisseria gonorrhoeae strains were inclusive (1) 50 historic from Japan with elevated fluoroquinolone minimal inhibitory concentration values (QRNG) (2) 200 contemporary clinical specimens in 2004 (176 6 sentinel sites the United States 24 bacteremic isolates SENTRY Antimicrobial Surveillance Program). rank order tested entire was: ceftriaxone (MIC(90) = 0.06 microg/mL) > (1 tetracycline (2 ciprofloxacin levofloxacin penicillin (4 microg/mL). activity not affected by penicillinase production; however, its decreased penicillin-resistant strains. Cross-resistance between older fluoroquinolones present, MIC90 value higher ciprofloxacin-resistant compared ciprofloxacin-susceptible versus 0.016 mug/mL, respectively). More than 20.0% recent resistant to penicillin, tetracycline, >30.0% gonococci Washington State Hawaii. QRNG Far East predominantly intermediate susceptibility (88.0%) ciprofloxacin, only 0.25 microg/mL. exquisitely susceptible 3 quinolones (ciprofloxacin, levofloxacin, gemifloxacin, at < or 0.03 (MIC90 In summary, competitive positioned that irrespective resistance phenotype. Gemifloxacin should be considered further development as therapeutic option treat uncomplicated infections due emerging penicillins, some fluoroquinolones.