Comparative sequence analysis and patterns of covariation in RNA secondary structures.
作者： John Parsch , Wolfgang Stephan , John M. Braverman
DOI: 10.1093/GENETICS/154.2.909
关键词:
摘要: A novel method of RNA secondary structure prediction based on a comparison nucleotide sequences is described. This correctly predicts nearly all evolutionarily conserved structures five different RNAs: tRNA, 5S rRNA, bacterial ribonuclease P (RNase P) RNA, eukaryotic small subunit and the 3' untranslated region (UTR) Drosophila bicoid (bcd) mRNA. Furthermore, covariations occurring in helices these are analyzed. Two physical parameters found to be important determinants evolution compensatory mutations: length helix distance between base-pairing nucleotides. For bcd UTR mRNA RNase positive correlation rate found. The analysis further revealed that decreases with residues. result qualitative agreement Kimura's model fitness interactions, which assumes mutations individually deleterious but become neutral appropriate combinations.
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