Feasibility of highly branched cyclic dextrin as an excipient matrix in dry powder inhalers.

摘要: We investigated the feasibility of highly branched cyclic dextrin (HBCD) as an excipient matrix in dry powder inhalers (DPIs). The fine particles HBCD and HBCD/active pharmaceutical ingredients (APIs) were prepared by spray-drying ethanol-aqueous solution containing HBCD. particle size spray-dried itself was approximately 3.0μm with a wrinkled shape. Solid-state fluorescence emission spectroscopy 1-naphthoic acid (1-NPA) showed that it dispersed molecular dispersion/solid solution, if model compound 1-NPA Powder X-ray diffraction differential scanning calorimetry indicate amorphous state after HBCD, which is confirmed measurements, could be incorporated into When antimycobacterial agent, rifampicin, for purpose pulmonary administration, emitted dose fine-particle fraction rifampicin 95.7±1.7% 39.5±5.7%, respectively. results indicated possessed high potential DPIs, not only association API molecules but also crystals.