Characterization of matrix embedded formulations for combination spray-dried particles comprising pyrazinamide and rifampicin
作者： Jun Yee Tse , Kazunori Kadota , Yoshiyuki Hirata , Masahiko Taniguchi , Hiromasa Uchiyama
DOI: 10.1016/J.JDDST.2018.09.013
关键词:
摘要: Abstract Dry powder inhalers (DPIs) are becoming increasingly popular in the treatment of both systemic and pulmonary diseases. In an effort to enhance DPIs, we developed spray-dried particles (SDP) using highly branched cyclic dextrin (HBCD) as excipient. Pyrazinamide (PZA) rifampicin (RFP) were employed present study. The cytotoxicity HBCD for excipient inhalable formulations was evaluated A549 cell lines a model alveoli cells. No cytotoxic effect observed. Moreover, unlike formulation prepared with PZA only, combination SDPs achieved fair fine particle fraction drugs, especially 40% ethanol concentration ratio which obtained (FPF) 48.7% ± 6.9% 51.2% ± 6.5% RFP, respectively. dissolution profile hydrophobic drug, RFP enhanced after being included composite powders. 60 min test, untreated can only obtain percentage 9.7% ± 2.5%, while near 100% when it had been into form, improvement may be contributed by acquired amorphous characteristics revealed PXRD analysis. deeper understanding on that through this study shows great potential applied additive preparing DPIs.
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