Impact of 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) on childhood pneumonia hospitalizations in Brazil two years after introduction.

摘要: Abstract Introduction Pneumococcal disease is a major public health problem worldwide. From March to September of 2010, 10-valent pneumococcal non-typeable Haemophilus influenzae protein conjugate vaccine (PHiD-CV) was introduced in the Brazilian childhood National Immunization Program (NIP) all 27 states. The aim present study report national time-trends incidence hospital admissions for pneumonia Brazil before and after two years introduction this new vaccine. Methods Analysis hospitalization data children aged 0–4 system with an admission diagnosis from 2002 2012 performed comparing pre (2002–2009) post-vaccination periods (2011–2012). Hospital number due non-respiratory diseases were obtained DATASUS, government open-access database system. Incidence compared admissions. Results Admission rates decreased steadily 2010 2012. In less than four years, hospitalizations 12.65% when (2011–2012) adjusted seasonality secular-trend ( p  = 0.39). Conclusion Childhood fluctuating prior significantly PHiD-CV introduction. Conversely, rate has shown no decrease. These are evidence effectiveness impact