Polymer-free drug-eluting stents

摘要: Drug-eluting stents (DES) have revolutionized the way that advanced coronary heart disease is now treated. These devices are associated with much lower rates of restenosis than their bare metal stent counterparts. However, presence a polymer coating on surface, which allows for incorporation and sustained release drug into artery, has been implicated in occurrence late thrombosis. Consequently, great many different polymer-free DES since developed. Early approaches involving direct loading to unmodified surfaces were largely ineffective, was likely due suboptimal delivery kinetics characterized by very rapid release. It found surface modification strategies at macro, micro nanoscale can be used provide more release, some these producing clinical results comparable polymer-coated DES. Emerging data use Cre8, BioFreedom, latest Drug Filled Stent from Medtronic Inc. suggest particular may inhibit without delaying recovery endothelium, would represent step change improvement performance. Whilst therefore appear particularly beneficial treating high bleeding risk patients, reduction antiplatelet therapy duration required an appealing feature see them make wider impact generally.