Comparação randomizada entre o stent eluidor de paclitaxel de nova geração sem polímero e o stent eluidor de paclitaxel com polímero durável em pacientes com doença arterial coronária: resultados da análise angiográfica e ultrassonográfica seriada do estudo PAX-A

摘要: ABSTRACT Randomized Comparison of a New-GenerationPolymer-Free Paclitaxel-Eluting Stent versus aDurable Polymer-Based Paclitaxel Eluting inPatients with Coronary Artery Disease: SerialAngiography and IVUS Results the PAX-A Trial Background: Increased rates late stent thrombosis afterfirst-generation drug eluting stents have prompted concernsabout its long-term safety. Local vascular inflammation anddelayed healing been identified as important substrates.Persistent polymer, anti-proliferative drug, or both, havebeen etiological factors. In presentstudy we sought to investigate performance efficacyof novel polymer-free Amazonia-PAX paclitaxel-elutingstent against first-generation, polymer-based Taxus Libertepaclitaxel-eluting stent. Methods: is prospective,randomized, single-blinded, single-center study, in whichpatients single de novo, < 20 mm lesions, nativecoronaries 2.5 3.5 diameter were randomizedto receive (n = 16) TaxusLiberte 15). Primary end-points in-stent lateluminal loss by QCA % obstruction volume byintravascular ultrasound (IVUS) at 4-month follow-up.Secondary included binary restenosis changesin vessel, lumen detected the4-month follow-up, well major adverse cardiac events[MACE: death, non-fatal myocardial infarction (MI) targetlesion revascularization (TLR)] one year.