Hormonal Predictors of Prostate Cancer

摘要: Introduction: Androgens are necessary for the development and functioning of prostate gland. The association serum testosterone pituitary hormone levels with cancer is not completely understood. In this clinical study, we evaluated role testosterone, free luteinizing (LH) follicle-stimulating (FSH) in predicting risk patients who had transrectal ultrasonography-guided biopsy suspicion cancer. Material Methods: A total 211 were selected to undergo prostatic due abnormal digital rectal examination and/or a prostate-specific antigen (PSA) level >2.5 ng/ml included study. patient characteristics PSA, free/total PSA ratio, FSH LH compared according pathological diagnosis. Results: mean age was 63.91 years (range 44–83) 9.23 0.13–50.41) whole group. Of patients, 69 (32.7%) positive statistically lower diagnosed as having benign hyperplasia (BPH; 405 vs. 450.5 ng/dl, respectively; p = 0.013). significantly higher men than BPH (7.56 6.06 mIU/ml, 0.029). No significant differences between those found levels. When normal ranges defined 9 pg/ml 300 respectively, low detection rates high androgen levels: 40.8% (40/98) versus 25.6% (29/113) (p 0.021), 48.6% (18/37) 29.3% (51/174), respectively 0.023). After logistic regression analysis, none hormones showed difference undergoing disease. Conclusion: Our data suggest that have BPH. support theory increase risk. Further studies needed clarify relationship etiology.