Seizure localization using three-dimensional surface projections of intracranial EEG power

摘要: Intracranial EEG (icEEG) provides a critical road map for epilepsy surgery but it has become increasingly difficult to interpret as technology allowed the number of icEEG channels grow. Borrowing methods from neuroimaging, we aimed simplify data analysis and increase consistency between reviewers by using 3D surface projections intracranial poweR (3D-SPIER). We analyzed 139 seizures 48 intractable patients (28 temporal 20 extratemporal) who had recordings, surgery, at least one year post-surgical follow-up. coregistered plotted β frequency band signal power over time onto MRI-based renderings each patient, create color 3D-SPIER movies. Two independent interpreted visual vs. 3D-SPIER, blinded any clinical information. Overall agreement rates or were about 90% side seizure onset, 80% lobe, just under sublobar localization. These improved when flexible thresholds ranges especially Interestingly, was better with good surgical outcome than poor outcome. Localization measurably faster considered qualitatively easier analysis. findings suggest that could be an diagnostic method presurgical localization in may also useful mapping normal brain function.