Improved Ventilation by Re-aeration of Atelectatic Regions with Exogenous Surfactant in Acute Respiratory Failure
作者： D. Gommers , B. Lachmann
DOI: 10.1007/978-88-470-2296-6_27
关键词:
摘要: Improved oxygenation, decreased ventilator requirements, and increased survival have been reported after tracheal administration of surfactant in premature infants with respiratory distress syndrome (RDS) [1]. It seems reasonable to assume that such improvement gas exchange is caused by an immediate lung volumes mechanics. However, studies which compliance was calculated from tidal (dynamic compliance) during mechanical ventilation surfactant-treated did not show any changes [2–4]. To understand the mechanisms behind improved oxygenation instillation, we first describe normal function pulmonary system, then discuss effects exogenous instillation on volume mechanics reviewing experimental clinical findings.
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