Changes in pulmonary mechanics after the administration of surfactant to infants with respiratory distress syndrome.

摘要: Abstract We assessed pulmonary mechanics in 35 premature infants with respiratory distress syndrome just before and one hour after the administration of 90 mg surfactant to each infant. Transpulmonary pressure was measured between airway opening an esophageal balloon use a differential transducer, flow rates were by pneumotachometer. Values for then calculated microcomputer processing. The produced large decrease (56 percent) mean (±SEM) ratio alveolar arterial oxygen, from 7.1±0.5 3.1±0.2 (P<0.0001) — change that indicates improvement gas exchange. Associated changes not demonstrable when 10 studied during continuous mechanical ventilation. However, 25 examined spontaneous breathing positive pressures (identical treatment), consistent improvements pulmona...