Evolution: a guide to perturb protein function and networks
作者： Olivier Lichtarge , Angela Wilkins
DOI: 10.1016/J.SBI.2010.04.002
关键词:
摘要: Protein interactions give rise to networks that control cell fate in health and disease; selective means probe these are therefore of wide interest. We discuss here Evolutionary Tracing (ET), a comparative method identify protein functional sites guide experiments selectively block, recode, or mimic their amino acid determinants. These studies suggest, principle, scalable approach perturb individual links networks.
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