Clinical Trial of Induced Hypothermia in Comatose Survivors of Out-of-Hospital Cardiac Arrest

摘要: Abstract Study objective: To examine the effects of moderate hypothermia (33 ° C), induced by surface cooling in ED and maintained for 12 hours ICU, on patients with anoxic brain injury after out-of-hospital cardiac arrest. Methods: We conducted study a teaching hospital Melbourne, Victoria, Australia. Participants were 22 adults who remained unconscious return spontaneous circulation following This treatment group was studied prospectively, control similar retrospective chart review. Moderate (33° C) means ICU rewarming to normothermia over 6 hours; at normothermia. Results: There no significant adverse hypothermia. Cardiovascular changes included decreased pulse rate, but there differences mean arterial blood pressure between two groups. Small increases serum potassium decreases pH 18 hypothermic compared normothermic controls clinical significance. septic complications. increase number good outcome (Glasgow Outcome Coma Scale category 1 or 2) (11 22, versus 3 controls; P Conclusion: Compared historical controls, significantly improved complications when comatose survivors arrest hours. Larger, prospective, randomized, controlled studies are warranted. [Bernard SA, Jones BM, Horne MK: Clinical trial Ann Emerg Med August 1997;30:146-153.]