The Pig as a Model to Assess the Effect of Class II MHC Antigen Matching on Renal Allograft Survival

摘要: Large animals such as dogs [1], monkeys [2], and swine [3] have been valuable models for transplantation biology both because of their size, which permits surgical manipulations similar to those in man, they provide an intermediate step between rodents man reexamine new experimental results. Although most biological principles are conserved among species, fine tuning the immune system is some cases different enough make results any one species not directly applicable man. Among known differences could potentially clinical ramifications transplants distribution class II MHC antigens on vascular endothelium [4] levels allogeneic resistance or graft-vs-host disease setting bone marrow [5, 6].