The Molecular Biology of JC Virus, Causative Agent of Progressive Multifocal Leukoencephalopathy

摘要: The rare demyelinating brain disease, progressive multifocal leukoencephalopathy (PML), was first described by Astrom and coworkers (1) in 1958, a viral etiology suggested Zu Rhein Chou (2) Silverman Rubinstein (3) 1965 based on electron microscopic analysis of infected cells. In 1971, Padgett et al. (4) reported the isolation virus from diseased tissue obtained at autopsy PML patient. Some have assumed incorrectly that name given to this virus, JC (JCV), identifies it as agent Creutzfeldt-Jacob but simply derived initials Structural antigenic studies (4, 5) demonstrated JCV previously unrecognized member genus Polyomavirus within family Papovaviridae. Additional members include closely related human monkey viruses, BK (BKV) SV40, more distantly type-species, mouse polyomavirus. No evidence has been presented associate BKV with disease. Also, although there reports an SV40 association (6, 7, 8, 9, 10, 11), we believe is now sufficient cast doubt for overwhelming data indicating cause fatal