Multiphoton imaging of cytotoxic T lymphocyte-mediated antitumor immune responses.

摘要: The actual contribution of T lymphocytes to protection against tumors is still unclear. In vitro imaging experiments show that tumor specific cytotoxic (CTLs) are competent kill target cells by conventional pathways. emergence multiphoton in the past decade now allows real time vivo CTLs. New insights available on behavior antitumor during priming phase, their traffic within tissue, and interactions with effector phase. Recent reports suggest direct killing CTLs a slow process, suggesting ratio determinant, or additional other cell types required induce efficient rejection. This review will focus publications have imaged immune responses dynamically discuss how this new information contributes understand implication