Two-photon imaging of intratumoral CD8+ T cell cytotoxic activity during adoptive T cell therapy in mice
作者： Béatrice Breart , Fabrice Lemaître , Susanna Celli , Philippe Bousso
DOI: 10.1172/JCI34388
关键词:
摘要: … In a mouse model of solid tumor, we found that tumor … action of CTLs on each individual tumor cell, with a minimal bystander … overall tumor volume was determined from confocal images …
dm5migu4zj3pb.cloudfront.net 参考文章(31)
M. Poenie, R. Y. Tsien, A. M. Schmitt-Verhulst, Sequential activation and lethal hit measured by [Ca2+]i in individual cytolytic T cells and targets. The EMBO Journal. ,vol. 6, pp. 2223- 2232 ,(1987) , 10.1002/J.1460-2075.1987.TB02494.X
Noriaki Sadanaga, Ulrike L. Burger, Maximilian P. Chang, Timothy J. Eberlein, Peter S. Goedegebuure, Makoto Nagoshi, Successful adoptive cellular immunotherapy is dependent on induction of a host immune response triggered by cytokine (IFN-gamma and granulocyte/macrophage colony-stimulating factor) producing donor tumor-infiltrating lymphocytes. Journal of Immunology. ,vol. 160, pp. 334- 344 ,(1998)
Sheila A. Caldwell, Mary H. Ryan, Elwood McDuffie, Scott I. Abrams, The Fas/Fas ligand pathway is important for optimal tumor regression in a mouse model of CTL adoptive immunotherapy of experimental CMS4 lung metastases. Journal of Immunology. ,vol. 171, pp. 2402- 2412 ,(2003) , 10.4049/JIMMUNOL.171.5.2402
Mythili Koneru, David Schaer, Ngozi Monu, Aidee Ayala, Alan B. Frey, Defective Proximal TCR Signaling Inhibits CD8+ Tumor-Infiltrating Lymphocyte Lytic Function Journal of Immunology. ,vol. 174, pp. 1830- 1840 ,(2005) , 10.4049/JIMMUNOL.174.4.1830
Brian K. Helmich, Richard W. Dutton, The Role of Adoptively Transferred CD8 T Cells and Host Cells in the Control of the Growth of the EG7 Thymoma: Factors That Determine the Relative Effectiveness and Homing Properties of Tc1 and Tc2 Effectors The Journal of Immunology. ,vol. 166, pp. 6500- 6508 ,(2001) , 10.4049/JIMMUNOL.166.11.6500
Makoto Nagoshi, Noriaki Sadanaga, Hong-Gu Joo, Peter S. Goedegebuure, Timothy J. Eberlein, Tumor‐specific cytokine release by donor T cells induces an effective host anti‐tumor response through recruitment of host naive antigen presenting cells International Journal of Cancer. ,vol. 80, pp. 308- 314 ,(1999) , 10.1002/(SICI)1097-0215(19990118)80:2<308::AID-IJC22>3.0.CO;2-O
Tanina A Cordaro, Karin E de Visser, Felicia H Tirion, Yvo MF Graus, John BAG Haanen, Dimitris Kioussis, Ada M Kruisbeek, None, Tumor size at the time of adoptive transfer determines whether tumor rejection occurs. European Journal of Immunology. ,vol. 30, pp. 1297- 1307 ,(2000) , 10.1002/(SICI)1521-4141(200005)30:5<1297::AID-IMMU1297>3.0.CO;2-C
Weiping Zou, Immunosuppressive networks in the tumour environment and their therapeutic relevance Nature Reviews Cancer. ,vol. 5, pp. 263- 274 ,(2005) , 10.1038/NRC1586
Michael T Spiotto, Donald A Rowley, Hans Schreiber, Bystander elimination of antigen loss variants in established tumors. Nature Medicine. ,vol. 10, pp. 294- 298 ,(2004) , 10.1038/NM999
C. Yee, J. A. Thompson, D. Byrd, S. R. Riddell, P. Roche, E. Celis, P. D. Greenberg, Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: In vivo persistence, migration, and antitumor effect of transferred T cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 16168- 16173 ,(2002) , 10.1073/PNAS.242600099