Tumor size at the time of adoptive transfer determines whether tumor rejection occurs.

摘要: Here we investigate the minimal requirements for induction of an anti-tumor response in CD8 T cells vivo. We compare efficacy adoptive transfer with a transgenic TCR specific main cytotoxic lymphocyte epitope influenza virus nucleoprotein (NP) on growth NP-expressing EL4 tumors under different conditions. In setting which tumor rejection is solely dependent tumor-specific cells, small immunogenic fail to induce response, despite fact that they are not ignored: activated, differentiate into effector and infiltrate bed. Nevertheless, does occur. sharp contrast, same tumor, when growing as large mass, rejected by transferred cells. The features distinguish mass from that, latter case, activated appear much later, smaller numbers. Efficacy thus dictated size at time transfer. These findings predict treatment residual disease will fail, unless vaccination also provided