Neuromodulation independently determines correlated channel expression and conductance levels in motor neurons of the stomatogastric ganglion

摘要: Neuronal identity depends on the regulated expression of numerous molecular components, especially ionic channels, which determine electrical signature a neuron. Such regulation at least two key factors, activity itself and neuromodulatory input. can modify currents in homeostatic or nonhomeostatic fashion. Neuromodulators typically by regulating properties levels subsets channels. In stomatogastric system crustaceans, both types have been demonstrated. Furthermore, coordinated channels that carry these has recently reported diverse neuronal systems, with neuromodulators not only controlling absolute current but also, over long periods time, appearing to their correlated expression. We hypothesize may regulate ion multiple cell-type-dependent report identified types, three are linearly pairwise manner, suggesting coexpression direct interactions, under normal conditions. each cell, some remain after input is removed, whereas correlations between other pairs either lost altered. Interestingly, different suite change correlation. At transcript level we observe distinct alterations channel mRNA amounts, including one cell lacking correlation conditions then gaining when removed. Synaptic does appear contribute, possible exception, transcripts code for respective conclude protein levels.