Alteration of Motor Network Function Following Injury

摘要: Abstract : We have made substantial progress over the past year with this proposal. Our primary goal is understanding of functional impacts removal descending inputs to motor network. determined that transient blockade causes changes in system whereby subsequent restored input unable re-establish normal output. However, we also a partial results an over-sensitivity network (full) connectivity. generated mechanistic both change sensitivity modulation, as well effects injury on underlying molecular and physiological processes crucial In addition, uncovered compensatory their mechanisms responsible for homeostatic plasticity changing physiology neurons attempt maintain excitability. All these shed light may be involved networks result removes control input.