Proctolin activates an inward current whose voltage dependence is modified by extracellular Ca2

摘要: The pentapeptide proctolin modulates the activity of rhythmic pattern generators in crustacean stomatogastric nervous system. Proctolin strongly excites lateral pyloric and inferior cardiac neurons ganglion (STG), causing them to fire extended high-frequency bursts action potentials (Hooper Marder, 1987; Nusbaum 1989a,b). We now report that depolarizes these cells maximally at membrane close threshold for potential generation. In voltage clamp, evokes an inward current, carried least partially by Na+, shows strong outward rectification. Removal extracellular Ca2+ markedly increases amplitude proctolin-evoked current linearizes its current-voltage curve. properties make it ideally suited contribute activity-dependent modulation network STG.