Pioneer GABA Cells Comprise a Subpopulation of Hub Neurons in the Developing Hippocampus

摘要: Summary Connectivity in the developing hippocampus displays a functional organization particularly effective supporting network synchronization, as it includes superconnected hub neurons. We have previously shown that function is supported by a subpopulation of GABA However, unclear whether cells are only transiently present or later develop into distinctive subclasses interneurons. These questions difficult to assess given heterogeneity neurons and poor early expression markers. To circumvent this conundrum, we used "genetic fate mapping" allows for selective labeling based on their place time origin. show early-generated form a neurons, characterized by an exceptionally widespread axonal arborization ability single-handedly impact dynamics when stimulated. Pioneer remain adulthood, they acquire classical markers long-range projecting Video Abstract