Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy.
作者： R. Cossart , C. Dinocourt , J. C. Hirsch , A. Merchan-Perez , J. De Felipe
DOI: 10.1038/82900
关键词:
摘要: Impaired inhibition is thought to be important in temporal lobe epilepsy (TLE), the most common form of adult patients. We report that, experimental TLE, spontaneous GABAergic was increased soma but reduced dendrites pyramidal neurons. The former resulted from hyperactivity somatic projecting interneurons, whereas latter probably due degeneration a subpopulation dendritic interneurons. A deficit could reduce seizure threshold, enhanced would prevent continuous occurrence epileptiform activity.
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