PLASTICITY | Axon Sprouting in Epilepsy

摘要: Most cases of temporal lobe epilepsy are believed to develop after a brain lesion. Reactive growth triggered by seizure-induced injuries strengthens monosynaptic recurrent excitatory circuitry in several regions, including the dentate gyrus. Studies gyrus animal models demonstrated formation novel granule-cell network epileptic brain: granule cells, either having or not basal dendrite, and newly-generated hilar ectopic cells synaptically interconnected mossy fibers. Formation this circuit is associated with reduced threshold for synchronization, properties suggest population could serve as trigger synchronized discharge. However, homeostatic changes residual GABA innervation reduce excitability. Important, still be elucidated, issues include: circumstances under which reverberating excitation overcomes restraints synchronize bursts, mechanisms inhibition recovers from loss interneurons, precise role seizure propagation, extent reorganization accounts cognitive/behavioral dysfunction persons lesional epilepsy.