Methadone and Related 3,3-Diphenylpropylamines

摘要: During World War II, chemists working in the Hoechst Laboratories of I. G. Farbenindustrie discovered that certain derivatives 3,3-diphenyl-N,N-dimethylpropylamine had analgesic properties. Details this work, acquired by Allies as one fruits victory,(1) provided a lead to novel class was followed with vigor on both sides Atlantic. The best-known member group is 6-dimethylamino-4,4-diphenylheptan-3-one (1, methadone, amidone, Physeptone), which introduced into clinical practice 1946; several variants obtained modifying basic and/or ketone function have also been marketed analgesics.