Interferon-β Signaling Contributes to Ras Transformation

摘要: Increasing evidence has pointed to activated type I interferon signaling in tumors. However, the molecular basis for such activation and its role tumorigenesis remain unclear. In current studies, we report that of (IFN) tumor cells is primarily due elevated secretion interferon, IFN-β. Studies oncogene-transformed suggest oncogenes as Ras Src can activate IFN-β signaling. Significantly, Ras-transformed mammary epithelial MCF-10A was shown contribute transformation evidenced by morphological changes, anchorage-independent growth, migratory properties. Our results demonstrate first time IFN, IFN-β, contributes support notion oncogene-induced cytokines play important roles oncogene transformation.