Ras oncogenes: split personalities

作者: Antoine E. Karnoub , Robert A. Weinberg

DOI: 10.1038/NRM2438

关键词: Signal transductionBiologyGeneticsRas oncogenesGTPase-activating proteinRegulation of gene expressionTranscription factorCarcinogenesis

摘要: … signalling was described by a number of groups in 1993, when it was demonstrated that the adaptor protein growth factor receptor-bound protein-2 (GRB2) associates with the EGF …

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