作者: Antoine E. Karnoub , Robert A. Weinberg
DOI: 10.1038/NRM2438
关键词: Signal transduction 、 Biology 、 Genetics 、 Ras oncogenes 、 GTPase-activating protein 、 Regulation of gene expression 、 Transcription factor 、 Carcinogenesis
摘要: … signalling was described by a number of groups in 1993, when it was demonstrated that the adaptor protein growth factor receptor-bound protein-2 (GRB2) associates with the EGF …