Alcohol, Cancer Genes, and Signaling Pathways

摘要: According to the International Agency for Research on Cancer (IARC), alcohol and its metabolite acetaldehyde, are considered be Group 1 carcinogens, defined as an agent (or mixture) with sufficient evidence of carcinogenicity in humans (Baan et al. 2007; Secretan 2009). Both animal vitro studies have shown that acetaldehyde is genotoxic, capable forming stable DNA adducts cause damage may lead cancer (reviewed by Brooks Theruvathu 2005; Seitz Stickel 2007). Although known DNA, only a handful attempted classify, molecular basis, tumor suppressor genes oncogenes affected consumption. This undertaking often ­complicated inability accurately quantify consumption context identifying these changes or presence confounding variables such tobacco use viral infection combination use.