Neurological manifestations of Behçet's disease in Japan: a study of 54 patients.

摘要: The type and frequency of neurological manifestations Behcet’s disease (BD) vary with ethnicity. We analyzed the BD in Japanese patients. All patients undergoing treatment at one two Yokohama City University hospitals from July 1991 to December 2007 who fulfilled criteria for revised 1987 were studied retrospectively by chart review. Patients had been neurologically assessed neurologists. recorded signs symptoms, magnetic resonance imaging or computed tomography findings, results cerebrospinal fluid examinations records each patient. 412 BD, whom 54 (13%) involvement (neuro-Behcet’s disease: NB). NB included a significantly higher proportion males (61%) than non-NB (42%, P = 0.009). majority (n 38, 70%) acute parenchymal NB, 15 (28%) chronic progressive 1 (2%) non-parenchymal type. Headache fever more frequently reported NB. Personality changes, sphincter disturbances, involuntary movements, ataxia occurred predominantly Lesions distributed throughout CNS, but mainly brainstem, white matter, basal ganglia. Analysis end-point clinical outcomes revealed poor prognosis In Japan, most have type, male gender is predisposing factor. Because unfavorable associated development effective therapies are urgently needed.