Anti-plasminogen autoantibodies from plasma of patients with systemic lupus erythematosus having anti-phospholipid antibody syndrome: isolation and some immunochemical properties.

作者: L. D. Kozmin , I. E. Shirokova , T. A. Lisitsina , T. V. Popkova , T. M. Reschetnyak

DOI: 10.1023/A:1023066503209

关键词:

摘要: Blood plasma samples from patients with systemic lupus erythematosus having the anti-phospholipid antibody syndrome were found to contain anti-plasminogen antibodies of IgG class. The titers autoantibodies class elevated in these compared normal controls. Part pool reacts an epitope lysine-binding sites plasminogen. Anti-plasminogen isolated patients' blood is specific only for a native human plasminogen passively adsorbed on immunosorbent micro-titration plate. As shown by enzyme immunoassay, cross-react fibrinogen.

参考文章(22)
John M. Walker, Basic protein and peptide protocols : Humana Press. ,(1994) , 10.1385/089603268X
Marja Puurunen, Matti Mänttäri, Vesa Manninen, Timo Palosuo, Outi Vaarala, Antibodies to prothrombin crossreact with plasminogen in patients developing myocardial infarction British Journal of Haematology. ,vol. 100, pp. 374- 379 ,(1998) , 10.1046/J.1365-2141.1998.00562.X
M Salazar-Paramo, P Cacoub, M Dominguez, E Angleés-Cano, P Godeau, I Garcia de la Torre, T J Piette, Autoantibodies to receptor induced neoepitopes of fibrinolytic proteins in rheumatic and vascular diseases. The Journal of Rheumatology. ,vol. 28, pp. 302- 308 ,(2001)
G. Markus, J.L. DePasquale, F.C. Wissler, Quantitative determination of the binding of epsilon-aminocaproic acid to native plasminogen. Journal of Biological Chemistry. ,vol. 253, pp. 727- 732 ,(1978) , 10.1016/S0021-9258(17)38163-2
D. W. Jones, M. J. Gallimore, I. J. Mackie, S. L. Harris, M. Winter, Reduced factor XII levels in patients with the antiphospholipid syndrome are associated with antibodies to factor XII. British Journal of Haematology. ,vol. 110, pp. 721- 726 ,(2000) , 10.1046/J.1365-2141.2000.02251.X
Francis J. Castellino, Recent advances in the chemistry of the fibrinolytic system Chemical Reviews. ,vol. 81, pp. 431- 446 ,(1981) , 10.1021/CR00045A001
Victoria A. Ploplis, Helen S. Cummings, Francis J. Castellino, Monoclonal antibodies to discrete regions of human Glu1-plasminogen. Biochemistry. ,vol. 21, pp. 5891- 5897 ,(1982) , 10.1021/BI00266A025
Wendell A. Wilson, Azzudin E. Gharavi, Takao Koike, Michael D. Lockshin, D. Ware Branch, Jean-Charles Piette, Robin Brey, Ronald Derksen, E. Nigel Harris, Graham R. V. Hughes, Douglas A. Triplett, Munther A. Khamashta, International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis & Rheumatism. ,vol. 42, pp. 1309- 1311 ,(1999) , 10.1002/1529-0131(199907)42:7<1309::AID-ANR1>3.0.CO;2-F
Robert A. S. Roubey, Immunology of the antiphospholipid antibody syndrome. Arthritis & Rheumatism. ,vol. 39, pp. 1444- 1454 ,(1996) , 10.1002/ART.1780390903