Molecular Definition of Pericentric Inversion Breakpoints Occurring during the Evolution of Humans and Chimpanzees

摘要: High-resolution G-banding analysis has demonstrated remarkable morphological conservation of the chromosomes Hominidae family members (humans, chimpanzees, gorillas, and orangutans), with most notable differences between genomes appearing as changes in heterochromatin distribution pericentric inversions. Pericentric inversions may have been important for establishment reproductive isolation speciation hominoids they diverged from a common ancestor. Here previously published primate karyotype comparisons, coupled resources Human Genome Project, used to identify inversion breakpoints seen when comparing human that chimpanzee. Yeast artificial chromosome (YAC) clones were detect, by fluorescence situ hybridization, five evolutionary present on chimpanzee equivalents 4, 9, 12. In addition, two YACs 12p detect breakpoint similar rearrangement gorilla.