Immunology of spermatozoa and cervical mucus

摘要: Auto-immunization of the male and iso-immunization female with spermatozoal or testicular material can lead to a significant impairment fertility. Interference sperm antibodies reproductive processes may occur by migration through cervix, uterus tubes blocking adherence spermatozoa surface zona pellucida oocyte. A very important point consider in this context is immunological situation genital tract which target organ for sex hormones. Observations human subhuman primates as well other mammalian species have shown that levels immunoglobulins specific secretions different compartments are low compared serum general show typical cyclic changes under influence oestrogens progesterone. Antibody appear be especially during preovulatory period cervical mucus and--according observations primates--in tubal fluid. Complement present borderline concentrations not detectable. Data on endometrial fluid scarce. However, their presence has been demonstrated. There indications secretory immune system operational mainly compartment tract. Serum antibody do reflect properly most instances. This male. Demonstrations even necessarily indicative permanent sterility; chances conception may, however, reduced. specificity, immunoglobulin class quantitative relationships between hormonal influences taken into consideration. Immunity does seem an all-or-nothing phenomenon should considered relative rather than absolute cause infertility.