Proteomic Expression Profiling of Breast Cancer

摘要: Breast cancer is one of the most common cancers observed in women industrialized Western countries. The development novel diagnostic methods and application modern systemic therapies have significantly optimized early detection therapy breast cancer. However, many patients are currently overtreated. Traditionally, tumours been categorized on basis histopathological criteria. staining pattern intensity cells not sufficient to reflect molecular events driving tumour progression. Therefore, new genomic, transcriptomic proteomic techniques applied clinical samples aiming identify targets for a tailored an individual patient. After introduction genomic profiling technologies their relevance use, we will focus analytical preanalytical applications identification therapeutic by protein profiling, with special emphasis two-dimensional gel-technologies (2D-PAGE), particularly as they apply study